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EVIK™ LyoPearl Retinol
A precision freeze-dried retinol bead combining Vitamin A with sodium hyaluronate for controlled dissolution, single-dose delivery, and formulation research.
How to Use
Dissolve one EVIK™ LyoPearl Retinol bead in the defined carrier volume before application. Follow the confirmed application protocol supplied by Evik Diagnostics.
Prepare
Add one EVIK™ LyoPearl Retinol bead to [CONFIRM: volume of carrier / water / serum]. Allow to dissolve fully before applying. Do not apply the bead directly to undiluted skin.
Apply
Apply the dissolved solution to the target skin area. [CONFIRM: timing, frequency, and any post-application instructions.]
Store
Use immediately after dissolution. After each use, close the vial cap tightly and return the vial to its desiccant pouch. Keep at room temperature away from direct light and moisture.
Why Lyophilized Format for Retinol?
Retinol is highly sensitive to environmental conditions, particularly light, oxygen, heat and formulation conditions. Conventional retinol serum formulations therefore require careful control of antioxidants, packaging, storage and dispensing conditions to help maintain retinol stability.
Lyophilization places the retinol into a dry formulation matrix with greatly reduced molecular mobility. When the formulation, packaging and manufacturing process are appropriately controlled, the dry state can help reduce degradation pathways associated with moisture and molecular movement. Retinol stability and potency should ultimately be confirmed through product-specific stability testing.
No Oxidation During Storage
The retinol is held in a dry matrix within the sealed bead, helping limit exposure to moisture and environmental conditions that can contribute to degradation.
Full Potency at Every Application
Each bead is manufactured as a defined single dose, providing approximately 1.21 mg retinol per LyoPearl based on the stated composition.
No Antioxidant Stabilisers Required in the Bead
The dry-state format is designed to provide physical protection against moisture-related degradation pathways without relying on a conventional liquid serum system.
Reduced Dependence on Liquid Packaging
The retinol remains in a dry bead until point of use, reducing the period during which the active is exposed to an aqueous formulation environment.
Polysorbate 20 Enables Aqueous Lyophilization
Retinol is oil-soluble and cannot be directly incorporated into an aqueous bead. Polysorbate 20 can act as a solubilizing system to enable incorporation during aqueous lyophilization.
Sodium Hyaluronate Co-Active
The formulation includes sodium hyaluronate at 9.1% dry weight alongside retinol, providing a defined co-active within the LyoPearl format.
Request a Sample
EVIK™ LyoPearl Retinol is available for research and evaluation. To request a sample, discuss dissolution protocol, target application concentration, or custom formulation options, contact the Evik Diagnostics team.
Want to understand the science behind retinol in skincare — how it works, what the clinical evidence shows, why retinol requires careful stability management, and how lyophilized delivery can support controlled point-of-use formulation?
Explore the science, clinical evidence and stability considerations behind EVIK™ LyoPearl Retinol.
Read: Retinol in Skincare — Science, Clinical Evidence & Stability →
